PSSD-Erectile dysfunction caused to ssri medications taken as anti depresssants

 

Post-SSRI Sexual Dysfunction (PSSD) is a condition that has garnered increasing attention in recent years due to its profound impact on individuals who have discontinued the use of selective serotonin reuptake inhibitors (SSRIs). SSRIs are commonly prescribed antidepressants known for their efficacy in treating mood disorders. However, for some individuals, the cessation of these medications does not mark the end of their side effects, particularly concerning sexual health.​

---

Understanding PSSD

PSSD refers to the persistent sexual dysfunction that continues or emerges after stopping SSRIs. This condition is characterized by symptoms such as genital numbness, reduced libido, erectile dysfunction, and anorgasmia. What makes PSSD particularly distressing is its persistence; symptoms can last for months or even years after discontinuation of the medication. The European Medicines Agency recognized PSSD in 2019, acknowledging that sexual dysfunction can endure after stopping SSRI or SNRI treatment .​Verywell Health+1The Guardian+1PubMed+2BioMed Central+2The Guardian+2

---

Symptoms and Diagnosis

The hallmark symptoms of PSSD include:​PSSD Network+5ScienceDirect+5PubMed+5

• Genital anesthesia or numbness

• Decreased sexual desire

• Erectile dysfunction in males

• Anorgasmia or pleasureless orgasms

• Reduced nipple sensitivity

• Emotional blunting

• Cognitive impairments

• Sleep disturbances​UK PSSD Association+5PubMed+5ScienceDirect+5The Guardian+8PSSD Network+8UK PSSD Association+8UK PSSD Association+3Verywell Health+3BioMed Central+3UK PSSD Association+1PSSD Network+1

Diagnosing PSSD involves a thorough evaluation to rule out other potential causes of sexual dysfunction. According to the PSSD Network, necessary criteria include prior treatment with a serotonin reuptake inhibitor and an enduring change in genital sensation after treatment stops. Additional criteria encompass a reduction in sexual desire, erectile dysfunction, and an inability to orgasm, persisting for at least three months after discontinuation .​UK PSSD Association+1PSSD Network+1BioMed Central+4PSSD Network+4RxISK+4

---

Prevalence and Impact

The exact prevalence of PSSD remains uncertain, partly due to underreporting and misdiagnosis. A study highlighted that 13.2% of patients treated with antidepressants reported persistent post-treatment genital hypoesthesia, compared to 0.9% of those treated with other medications . The impact of PSSD on individuals is profound, affecting not only sexual health but also emotional well-being, relationships, and overall quality of life.​RxISK+1PubMed+1

---

Potential Mechanisms

The pathophysiology of PSSD is not fully understood, but several theories have been proposed:​PubMed

• Neurotransmitter Imbalance: SSRIs increase serotonin levels, which may suppress dopamine, a neurotransmitter crucial for sexual function.​

• Receptor Downregulation: Chronic SSRI use may lead to downregulation of certain serotonin receptors, affecting sexual response.​

• Epigenetic Changes: SSRIs might induce long-lasting changes in gene expression related to sexual function PubMed.​

• Neurotoxicity: Some researchers suggest that SSRIs could have neurotoxic effects on pathways involved in sexual arousal and response PubMed.​

---

Treatment and Management

Currently, there is no universally accepted treatment for PSSD. Management strategies are largely symptomatic and may include:​

• Pharmacological Interventions: Some patients have tried medications like bupropion, which has dopaminergic activity, with varying success.​

• Psychotherapy: Addressing the psychological impact of PSSD through counseling or therapy can be beneficial.​

• Lifestyle Modifications: Regular exercise, a healthy diet, and stress management techniques may help improve overall well-being.​

Research into treatments like low-power laser irradiation and phototherapy has shown some promise, but more studies are needed to establish efficacy ScienceDirect.​

---

Advocacy and Awareness

Organizations like the PSSD Network and the UK PSSD Association are working to raise awareness about the condition, advocate for research funding, and provide support to those affected. They emphasize the importance of informed consent when prescribing SSRIs, ensuring patients are aware of potential long-term side effects.​UK PSSD Association+1The Guardian+1Verywell Health+1The Guardian+1

---

Conclusion

PSSD is a complex and often misunderstood condition that can have a significant impact on an individual's life. While SSRIs are effective for many in treating depression and anxiety, it's crucial to recognize and address the potential for persistent sexual side effects. Ongoing research, increased awareness, and patient advocacy are essential steps toward better understanding and managing PSSD.​PubMed+1Verywell Health+1

---

References:

self respect| companies to treat individuals with proper respect

Self-respect is the cornerstone of a fulfilling life and a thriving workplace. It shapes how we perceive ourselves, interact with others, and navigate challenges. When individuals and organizations prioritize self-respect, they cultivate environments where dignity, productivity, and mutual appreciation flourish.​

---

Understanding Self-Respect

At its core, self-respect involves recognizing one's inherent worth and maintaining a positive self-image. It's about setting boundaries, making decisions aligned with personal values, and treating oneself with kindness and dignity. This internal compass guides behavior, fosters resilience, and influences how others perceive and treat us.​

---

The Role of Self-Respect in the Workplace

In professional settings, self-respect manifests in various ways:​

• Autonomy: Individuals with self-respect take initiative, make informed decisions, and accept responsibility for their actions.​

• Assertiveness: They communicate their ideas and needs confidently, fostering open and honest dialogue.​

• Resilience: Self-respecting employees handle setbacks constructively, viewing challenges as opportunities for growth.​

These qualities contribute to a positive work environment, enhancing collaboration, innovation, and overall job satisfaction.​

---

Companies That Prioritize Respect

Organizations that treat employees with respect reap significant benefits. For instance, Nvidia, a leading technology company, is renowned for its supportive work environment, flexible practices, and substantial employee benefits. Such an approach has been linked to higher employee satisfaction and improved financial performance. ​

Similarly, Teleperformance emphasizes treating employees as internal customers, focusing on mental health, diversity, and inclusion. Their commitment to employee well-being has earned them recognition as a top employer in India. ​TP | Digital Business Services+1Business Insider+1

---

Cultivating Self-Respect: Practical Steps

Building self-respect is an ongoing process that involves intentional actions:​The Times of India+4Medium+4Question AI+4

1. Set Boundaries: Clearly define your professional limits to maintain balance and prevent burnout.​Medium

2. Acknowledge Achievements: Celebrate your successes and recognize your contributions to foster a positive self-image.​

3. Continuous Learning: Invest in personal and professional development to enhance competence and confidence.​

4. Effective Communication: Express your thoughts clearly and listen actively to build mutual respect.​

5. Positive Self-Talk: Replace negative thoughts with affirmations that reinforce your value and capabilities.​

Implementing these strategies can lead to increased productivity, job satisfaction, and a healthier work-life balance. ​Medium

---

The Impact of Respectful Workplaces

Workplaces that foster self-respect and mutual respect experience numerous advantages:​

• Enhanced Collaboration: Employees feel valued and are more willing to contribute ideas and support colleagues.​

• Higher Retention Rates: Respectful environments reduce turnover by promoting employee satisfaction and loyalty.​

• Improved Performance: A culture of respect motivates employees to perform at their best, driving organizational success.​

By prioritizing respect, companies not only enhance employee well-being but also achieve better business outcomes.​

---

Conclusion

Self-respect is integral to personal fulfillment and professional excellence. When individuals uphold their dignity and organizations cultivate respectful cultures, everyone benefits. Embracing self-respect leads to empowered employees, cohesive teams, and thriving businesses.​The Times of India+4HRM online+4Medium+4

Ashwagandha | hair growth|how to have hair regrowth

Ashwagandha one of the best ayurvedic product of ancient times which has numerous benefits such as building muscles, hair growth, reduces stress, improves sex life etc.



                                                                  Ashwagandha contains antibacterial, anti-inflammatory, antifungal properties which help in treating scalp issues such as dandruff, scalp psoriasis, and itchiness.

                                                                   It contains protein ingredients that strengthen our hair and make our hair shaft less prone to breakage. Ashwagandha helps in blood circulation to scalp resulting in follicle stimulation which leads to more hair growth and is great at combating alopecia.



                                                                   Ashwagandha helps in stopping loss of melanin in hair shaft which prevents hair graying. It contains tyrosine which is the amino acid that stimulates melanin production and antioxidants within Ashwagandha which prevents corrosion of the tissues in the hair shaft.

Moto G6 Plus|review of Moto G6 Plus

Moto G6 Plus is now in stores whose amazign features are as follows:

Smart camera system a 15 cm(5.9) full HD + Max vision display with an 18:9 aspect ratio 6 GB of Ram and a blazing fast 2.2 GHz processor.


                                                                    

on-page optimization|benefits of on-page seo

what is SEO? SEO stands for search engine optimization part of digital marketing(online marketing) for product or services of a website(web pages).SEO is divided into category 1)on-page and off-page
Here we are going to know about on-page SEO. It is the strategy applied on webpage/website to make the site SEO friendly and attract users to site.

  Things included in on-page SEO are as follows:

1) keyword research
2)writing meta tags
3)writing content(content optimization)
4) image optimization
5)Url mapping
6)internal linking

After keyword research keywords are extracted or selected to be used on your website are kept in excel file which is used in further processes. Then Url mapping is done for the keywords and the pages need to be optimized in a website.

Using those keywords you can write meta tags such as title tags and description tags and keyword tags for pages which were mapped.keywords are used in the content for pages of 1000 words(content optimization)minimum including h1,h2,h3 header tags in the content.

We can use keywords in images using ALT tags for image optimization which is necessary to optimize as crawlers can't optimize image so Alt tags are used for image optimization using keywords.

Internal linking is linking of web pages in a website to increase authority of site by transfer of link juice came from link building(from backlinking from authoritative relevant sites) between pages in a website which increase the value of the website.For that, the site structure should be good enough that within3-4 clicks you can reach the internal links from home page which helps in ranking in google.

Finally you can use keywords in url which should be short for ranking.

The seo ranking factor you must master in 2018 and beyond

There is three SEO ranking factor you need to master in 2018 which are as follows:

1)bucket brigades:


2) Benefit-driven subheading


3)APP formula

why does motivation doesn't work for long ?|motivation speech|life motivation

Motivation is a short-term realization of achieving a goal which creates a sensation of success. Nowadays lot's of motivation speaker is there to give you life motivation and make you realize of achieving success.



                                                           People are aware of all sorts of things to get success because of the internet era because of lot's of the motivational programme is arranged. Then why do all people or the majority of people are not getting success?


                                                               Is destiny, luck fate is everything in getting success? Or there is some scope of human beings hard work is there to create his/her own destiny. Those people who are highly successful in there life may/may not wait for someone motivation or motivational speech to achieve success. Not they waited for the right time to come to achieve something.


                                                                          Even though destiny, fate is there something but without work/action no person can achieve greatness. Why Does human being is called as greatest of all creations of GOD? It's because Human beings are given with a brain whose power is still can't be measured, it's so powerful that human beings are above all creatures in the world and that's why if we compare to the past with the present lot's of things are invented which a logical brain can't think in the past, as people judge themselves in present or past information and get stuck in limited belief so they can't able to achieve greatness and shift there thinking to believe that some people are born to do all great things or born with special talent and rest of us are born to live a average or below average or to live a poor life.

                                                But if people's life is confined to there destiny then no use of called as greatest among all creatures as we also live like animals of limited possibilities. If GOD Has given a destiny/fate/luck like things which we learned here in this world but it is also a big truth that human beings can achieve bigger things in life if he is really willing to get and for that no motivation is required only by thinking or reading the achievements of others and why ur great than others creatures makes you believe that you can also do the impossible if you are willing to

                                                                        So to achieve success two important things are necessary that is what you want and belief to achieve that. Then accordingly other things come into the front that is clarity, direction, hard work.